Warty dyskeratoma wd, also known as isolated follicular dyskeratosis, is a relatively uncommon benign epidermal proliferation first reported by szymanski in 1957. Isolated lesions with histologic features almost indistinguishable from those in darier disease were first given special standing by helwig. Warty dyskeratoma wd, also known as isolated follicular dyskeratosis, is relatively uncommon benign epidermal proliferation first reported by szymanski in 19571. Treatment of warty dyskeratoma with tazarotenic acid. Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. Trichilemmomas are benign follicular neoplasms that exhibit differentiation toward the outer root sheath of the pilosebaceous follicular epithelium. An elderly woman had a small verrucose hyperkeratotic papule on the hard palate. Phelps and others published warty dyskeratoma of the eyelid find, read and cite all the research you need on researchgate. Warty dyskeratoma may represent an abnormal keratinization response to intraoral trauma or inflammation. Outcomesresolutions the prognosis of warty dyskeratoma is excellent on its surgical removal, in most cases. A high proportion of the rare genital, crural, and perineal cases referred to as papular acantholytic dyskeratosis see above have had a histological resemblance to haileyhailey disease, with prominent acantholysis and little or no dyskeratosis. Case of warty dyskeratoma with unique dermoscopic features.
Pdf warty dyskeratoma involving two adjoining follicles. Wd presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face. To our knowledge, our case includes the first description of this lesion on the vocal cord. Warty dyskeratomafocal acantholytic dyskeratosis an update. Wd presents as a whitish or grayish solitary papule or small nodules with a keratotic plug, usually limited to the head and neck of middleaged patients. A case of warty dyskeratoma on an unusual location rambhia kd. View large image view hires image download powerpoint slide. Warty dyskeratomafocal acantholytic dyskeratosisan update. Warty dyskeratoma, also known as localized darier disease, is a very uncommon lesion that can develop on either the skin or oral mucosa.
An unusual location of subungual warty dyskeratoma. Lesions are generally solitary but grouped verrucous papules on the scalp. Clinical findings are similar to verruca vulgaris, irritated seboreik. Warty dyskeratoma, also known as an isolated dyskeratosis follicularis. Plaque form of warty dyskeratoma acantholytic dyskeratotic. Treatment of warty dyskeratoma with tazarotenic acid sciencedirect. Acantholytic dyskeratosis an overview sciencedirect topics. Warty dyskeratoma wd is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. Warty dyskeratoma journal of the american academy of dermatology. Suprabasal acantholysis of the epidermis is a histopathologic common denominator of diverse conditions such as pemphigus vulgaris, benign familial pemphigus haileyhailey, transient acantholytic dermatosis grovers disease, some actinic keratoses and cutaneous squamous carcinomas.
We present an unusual location of warty dyskeratoma in the nail bed using a clinicohistopathological correlation for the diagnosis. Of these 112 cases, 88 were located on the head or neck, 17 on the trunk, three on the extremities upper, one on the buccal mucosa, and three in unknown areas. Warty dyskeratoma, also known as localized darier disease, is a very uncommon lesion that can develop on either the skin or oral. Warty dyskeratoma wd is regarded as a benign follicular adnexal neoplasm. Warty dyskeratoma wd is a benign solitary lesion of unknown aetiology affecting the skin and oral mucosa. Warty dyskeratoma, also known as isolated dyskeratosis follicularis, is a benign keratization disorder characterized. According to some authors, majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm. Histologic examination showed the lesion to be a warty dyskeratoma.
Warty dyskeratoma is a solitary lesion of unknown etiology that has microscopic resemblence to dariers disease. Widespread keratosis follicularis is an entity that has been familiar to dermatologists since it was described by darier in 1889. Dyskeratoma definition of dyskeratoma by medical dictionary. Pdf dermoscopy of multiple warty dyskeratomas researchgate. Pdf warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or. Warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middleaged or older persons. The cause is unknown, although the microscopic features are very similar to those of darier disease. Introduction warty dyskeratoma wd is an unusual benign tumour with a follicular origin.
This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Clinical findings are similar to verruca vulgaris, irritated seboreik keratoses and hypertrophic actinic keratoses. Warty dyskeratoma wd of the right lower eyelid in a 60yearold woman presenting as a slowly growing papule. Warty dyskeratoma is a benign dermatose that is characterized by a soliter papule or a nodule. It was called warty dyskeratoma by szymanski in 1957. Skin warty dyskeratoma, or follicular dyskeratoma, is a relatively uncommon, benign, follicular adnexal neoplasm that usually appears between the 5th and 7th decades of life and is most prevalent in white men. Manual dermoscopy revealed a pale, homogeneous area mottled by 3 brown to yellow marbled clods adjacent to several. The histopathology shows a pattern of acantholytic dyskeratosis. Warty dyskeratoma frequently arises as a single lesion with a central keratotic plug on the skin of middleaged or elderly people. Warty dyskeratoma of the leg jama dermatology jama network. Jan 23, 2017 warty dyskeratoma wd is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. Warty dyskeratoma wd is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. The pathogenesis remains uncertain, but uv light, autoimmunity, and smoking may play a role.
A patient with warty dyskeratoma was successfully treated with tazarotenic acid gel. We report a 32yearold man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first. Multiple warty dyskeratomas are very rare cutaneous lesions which are mostly seen on the scalp. Warty dyskeratoma involving two adjoining follicles.
It usually presents as a solitary, asymptomatic umbilicated papule, most often in the head and neck region of middle to olderage adults. Warty dyskeratoma is a tiny, nodular lesion with a characteristic histologic picture that resembles that of dariers disease. Additional and relevant useful information for warty dyskeratoma. White homogeneous area with 3 yellow clods with intervening hair follicles arrows. Warty dyskeratoma definition of warty dyskeratoma by. Because it often arises in association with a dilated hair follicle, it has been postulated to have a follicular origin. When it occurs in the oral cavity, wd is most commonly seen on the hard palate. Warty dyskeratoma of the buccal mucosa request pdf.
We present evidence to support that this did not occur by chance and suggest that tazarotenic acid be investigated further for the treatment of similar dyskeratatic disorders. Histologically, it shows a cupshaped keratinfilled invagination of an acanthotic epidermis, suprabasilar. Warty dyskeratomafocal acantholytic dyskeratosis an update on a rare oral lesion irit allon department of oral pathology and oral medicine, school of dental medicine, tel. Histologically similar lesions have been described in the oral region mainly by case reports and under the terms wd or focal acantholytic dyskeratosis fad. Warty dyskeratoma isolated dyskeratosis follicularis is generally thought of as a cutaneous lesion of the head and neck regions. However, azuma has reported a case of multiple warty dyskeratomas of the scalp, neck, cheeks and hands, similar to the two cases we present, and he suggests a follicular origin for the lesions, as clinically they arc follicularly based, and upon histological examination, early lesions are associated with sebaceous glands. Warty dyskeratoma wd, also known as isolated darier disease or focal acantholytic dyskeratosis,1 is a rare mucocutaneous lesion. Pdf dermoscopy of multiple warty dyskeratomas semantic. Until now, these changes have been described only on the skin and the mucosa of the oral cavity.
Ko, md key facts clinical issues solitary very rarely multiple umbilicated papule or nodule often on head or neck microscopic pathology cupshaped lesion sometimes associated with hair follicles hyperkeratosis and parakeratosis suprabasilar acantholysis with villi at base mixed inflammatory infiltrate in dermis. Wd presents as a whitish or grayish solitary papule or as a small nodule with a keratotic plug, usually limited to the head and neck of middleaged patients. Pdf warty dyskeratoma is a rare tumor that presents mainly as an isolated papule or nodule on the scalp, face or neck in the adults. Warty dyskeratoma of the oral mucosa british journal of oral and. Multiple warty dyskeratomas are a rare occurrence and their. Plaque form of warty dyskeratoma acantholytic dyskeratotic acanthoma. While warty dyskeratoma of the oral mucosa is rare, it appears to exhibit a. Graham and helwig first described warty dyskeratoma as isolated dariers disease in 1954. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Dermoscopy of multiple warty dyskeratomas dermatology. A note concerning its occurrence on the oral mucosa. It usually appears as a solitary reddishbrown papule, but cases of multiple lesions have been observed.
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